In Desolation's Wake

In Desolation's Wake Act VI

Location	Burning Hells
Previous Quest	Essence of Hatred
Next Quest	Light Extinguished
Reward	26,892 XP 2,640 Gold

In Desolation's Wake is a Main Quest in Diablo 4. In Desolation's Wake can be found at the Burning Hells. Main Quests are mandatory missions that players must complete in order to finish the storyline and reach the next difficulty level. Main Quests must be done sequentially and are unlocked only after completing the previous Main Quest/s.

Diablo 4 In Desolation's Wake Objectives

Speak to Donan
Escort your allies through the Realm of Hatred
Defeat the ambushers in the Burning Hells
Escort your allies through the Realm of Hatred
Speak to Lorath
Kill Karum, Hound of Hatred
Guide your allies through the Twisted Pathway
Defeat the Demons
Kill Remaining Demons
Follow Lorath
Speak to Lorath
Defeat Ashava

Diablo IV In Desolation's Wake Walkthrough

At the end of Essence of Hatred, you recovered the soulstone Inarius took from you. Speak to Donan to kick off the quest. You'll be following your allies and defeating any enemies that block your way. Enemies you'll encounter include Annihiliators, Balrogs, Sin Eaters, Soul Burners, Spawn of the Damned, Succubi, Vile Ones, Vile Overseers, and their Elite versions.

Donan will eventually warn you that an ambush is coming. While he and Lothar prepare a bulwark, climb up the cliff to their left to encounter Ninsa, Blight of Hatred. Though she has a boss health bar, taking her down to her health bar down to the first triangle will cause her to flee. At the start of the fight, defeat the four Soul Burners she's tethered to to make her vulnerable, then deal a quarter of her health to end the fight for now. Vile Lunatics and Vile Shamans will come up the hill after she flees.

Continue forward around the bend to rejoin your allies. Neyrelle will dispel the first flame barrier with no issue, but at the next flame barrier, you'll have to protect Neyrelle from the boss Karum, Hound of Hatred.

After you've defeated Karum, head northeast and jump across the gap. Continue jumping across the gaps, defeating or ignoring the enemies in your way, and stock up on Health Potions at the Healing Well. Ahead, you'll have the opportunity to finish off Ninsa. When you get to the entrance of the next clearing, Nins, Blight of Hatred will swoop down from above with a quarter of her health missing. Whenever Donan says to take cover or to get inside the barrier, make sure you're standing in their purple bubble to avoid getting damaged by the falling AOE attacks.

Defeat Ninsa and all the demons with her to proceed. Follow Lorath to the center of the room and speak with him. Prepare for another boss fight as after the conversation ends, you will have to fight Ashava, the Pestilent.

After Ashava has been defeated, In Desolation's Wake will end, granting you 26,892 XP and 2,640 Gold. The next quest, Light Extinguished, will unlock shortly after.

How to unlock In Desolation's Wake in Diablo 4

Complete the Main Quest, Essence of Hatred